2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists was written by Kang, Jin Mi;Kwon, Sun Ok;Ann, Jihyae;Lee, Sunho;Kim, Changhoon;Do, Nayeon;Jeong, Jin Ju;Blumberg, Peter M.;Ha, Heejin;Vu, Thi Ngoc Lan;Yoon, Sanghee;Choi, Sun;Frank-Foltyn, Robert;Lesch, Bernhard;Bahrenberg, Gregor;Stockhausen, Hannelore;Christoph, Thomas;Lee, Jeewoo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Name: Ethyl 2-fluorophenylacetate This article mentions the following:
A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure-activity anal. targeting their three pharmacophoric regions indicated that halogenated Ph A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists I and II exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, resp. Further, antagonist II displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A mol. modeling study of II indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Name: Ethyl 2-fluorophenylacetate).
Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: Ethyl 2-fluorophenylacetate
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