Synthesis of 4,5-Diaryl-1H-pyrazole-3-ol Derivatives as Potential COX-2 Inhibitors was written by Patel, Meena V.;Bell, Randy;Majest, Sandra;Henry, Rodger;Kolasa, Teodozyj. And the article was included in Journal of Organic Chemistry in 2004.Computed Properties of C10H11FO2 This article mentions the following:
4,5-Diaryl-1H-pyrazole-3-ol was utilized as a versatile template to synthesize several classes of compounds such as pyrazolooxazines, pyrazolobenzooxazines, pyrazolooxazoles, and annulated pyrazolooxazoles as potential COX-2 inhibitors. The pyrano- and thiopyranopyrazolooxazoles were successfully synthesized with use of pyridinium p-toluenesulfonate mediated cyclization of ketal intermediates. Diarylpyrazolobenzooxazepine analogs were synthesized by using Cu-mediated cyclization of O-alkylated aryl bromide intermediate. Arylsulfonamides were synthesized efficiently on a large scale with the 4-[4-(4-fluorophenyl)-5-hydroxy-2H-pyrazol-3-yl]benzenesulfonamide template readily synthesized from com. available 4-sulfamoylbenzoic acid. The structure of a representative compound from each class was confirmed by X-ray crystallog. Selected compounds tested for inhibitory activity against COX-1 and COX-2 enzymes showed good selectivity for COX-2 vs. COX-1 enzyme. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Computed Properties of C10H11FO2).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C10H11FO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics