An efficient one-pot construction of substituted pyrimidinones was written by Lu, Yuelie;Xiang, Tingjian;Bartberger, Michael D.;Bernard, Charles;Bostick, Tracy;Huang, Liang;Liu, Longbin;Siegmund, Aaron;Sukay, Gregory;Guo, Gary;Elipe, Maria Silva;Tormos, Wanda;Dominguez, Celia;Koch, Kevin;Burgess, Laurence E.;Basil, Thomas C.;Ibrahim, Prabha;Hummel, Conrad. And the article was included in Tetrahedron in 2006.SDS of cas: 587-88-2 This article mentions the following:
A concise, scalable synthesis of 5-aryl-3-methyl-2-methylthio-6-pyridin-4-yl-3H-pyrimidin-4-ones (aryl = 3-MeC6H4, 4-FC6H4, 3,4-Cl2C6H3, 2-naphthyl, etc.), as building block for p38 kinase inhibitor B, from Et arylacetates, 4-cyanopyridine and Me isothiocyanate is described. Subsequent hydrolysis of the methylthio group to the hydroxy group and chlorination provided the key intermediates, 2-chloro-3-methyl-6-pyridin-4-yl-5-aryl-3H-pyrimidin-4-ones. This class of reactive building blocks enabled the rapid evaluation of a variety of side chains at the 2-position of the pyrimidinone in SAR studies of inhibitors of p38 MAP kinase. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2SDS of cas: 587-88-2).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 587-88-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics