3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts was written by Brnardic, Edward J.;Fraley, Mark E.;Garbaccio, Robert M.;Layton, Mark E.;Sanders, John M.;Culberson, Chris;Jacobson, Marlene A.;Magliaro, Brian C.;Hutson, Pete H.;O’Brien, Julie A.;Huszar, Sarah L.;Uslaner, Jason M.;Fillgrove, Kerry L.;Tang, Cuyue;Kuo, Yuhsin;Sur, Sylvie M.;Hartman, George D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Recommanded Product: 16413-26-6 This article mentions the following:
Hit to lead optimization of (5R)-5-hexyl-3-phenyl-1,3-oxazolidin-2-one as a pos. allosteric modulator of mGluR2 is described. Improvements in potency and metabolic stability were achieved through SAR on both ends of the oxazolidinone. The optimized lead compound 34 (I) was found to be brain penetrant and active in a rat ketamine-induced hyperlocomotion model for antipsychotic activity. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 16413-26-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics