Rhenium-Catalyzed Construction of Polycyclic Hydrocarbon Frameworks by a Unique Cyclization of 1,n-Diynes Initiated by 1,1-Difunctionalization with Carbon Nucleophiles was written by Murai, Masahito;Uemura, Erika;Hori, Shunsuke;Takai, Kazuhiko. And the article was included in Angewandte Chemie, International Edition in 2017.COA of Formula: C10H14O4 This article mentions the following:
A regioselective cyclization of 1,n-diynes under rhenium catalysis was developed on the basis of a rare type of 1,1-difunctionalization of terminal alkynes with carbon nucleophiles, followed by sequential addition reactions of the resulting alkenylrhenium species. The reaction provides an efficient approach to the synthesis of complex cyclopentane-fused bi- and tricycles and spirocycles, which are useful building blocks for the construction of essential frameworks of biol. active compounds as well as functional materials, from simple starting materials by the formation of up to six new carbon-carbon bonds in a single step. The reaction proceeds under neutral conditions and does not require external ligands or additives. The key to this reactivity is the unique activation mode of the rhenium carbonyl complex, which prefers to interact with heteroatoms in polar carbon-heteroatom bonds as well as nonpolar carbon-carbon unsaturated 锜?bonds. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9COA of Formula: C10H14O4).
Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C10H14O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics