灏?Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in鑱?em>silico and in鑱?em>vitro cytotoxicity studies was written by Ragavan, Ramasamy Venkat;Kumar, Kalavathi Murugan;Vijayakumar, Vijayaparthasarathi;Sarveswari, Sundaramoorthy;Ramaiah, Sudha;Anbarasu, Anand;Karthikeyan, Sivashanmugam;Giridharan, Periyasamy;Kumari, Nalilu Suchetha. And the article was included in Organic and Medicinal Chemistry Letters in 2013.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:
A series of pyrazolones I [R1 = Ph, 4-MeOC6H4, cyclohexyl, 3-Cl(CH2)3, etc.; R2 = H, Me, Et; R3 = H, 4-FC6H4; R1R2 = (CH2)6, (CH2)8, etc.] were synthesized via cross-Claisen condensation of ketones and Et chloroformate to give 灏?keto esters which further reacted with hydrazine derivatives, and their cytotoxicity and antimicrobial activity were studied. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).
Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics