Development of a Practical and Scalable Synthesis of (R)- and (S)-3-Amino-2-[(benzyloxy)methyl]propan-1-ol Monohydrochloride: A Useful C-4 Chiral Building Block was written by Yoshida, Shinya;Obitsu, Kazuyoshi;Hayashi, Yasumasa;Shibazaki, Mitsuyoshi;Kimura, Takenori;Takahashi, Takumi;Asano, Toru;Kubota, Hirokazu;Mukuta, Takashi. And the article was included in Organic Process Research & Development in 2012.Related Products of 82962-54-7 This article mentions the following:
The development of a practical and scalable synthesis of a C-4 chiral amine building block (R)-1璺疕Cl and (S)-1璺疕Cl is described. This important chiral intermediate (R)-1璺疕Cl is efficiently synthesized from the com. available, inexpensive, and simple 2-(hydroxymethyl)-1,3-propanediol using lipase-catalyzed enantioselective hydrolysis as a key reaction. Development resulted in a telescoped process that was operated successfully and reproducibly in a pilot-plant-scale synthesis, and 22 kg of chiral amine (R)-1璺疕Cl was prepared in the first scale-up synthesis. This synthetic method is also useful for preparation of the important chiral building block (S)-1璺疕Cl, which is the enantiomer of (R)-1璺疕Cl. In the experiment, the researchers used many compounds, for example, Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7Related Products of 82962-54-7).
Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 82962-54-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics