Transition-metal peroxide reactions. Synthesis of 浼?hydroxycarbonyl compounds from enolates was written by Vedejs, E.;Engler, D. A.;Telschow, J. E.. And the article was included in Journal of Organic Chemistry in 1978.SDS of cas: 15399-05-0 This article mentions the following:
Enolates of ketones, esters, and lactones were oxidized by MoO5.OP(NMe2)3.pyridine (I) to give 浼?hydroxy derivatives The reaction succeeds with carbonyl compounds having 浼?methylene or 浼?methine groups, but enolates from methyl ketones gave variable results. Thus, treatment of Me(CH2)5CO2Me with (Me2CH)2NLi in THF-hexane at -70鎺?and subsequent addition of I gave 74% Me(CH2)4CH(OH)CO2Me; similarly, 3灏?methoxypregna-5,16-dien-20-one gave 52% 21-hydroxy-3灏?methoxypregna-5,16-dien-20-one. The hydroxylation process did not give products of oxidative C-C cleavage, which formed from an 浼?hydroperoxycarbonyl intermediate. If the initial intermediate from an enolate and I was heated, further oxidation to an 浼?dicarbonyl compound occurred in poor yield. Hydroxylation of kinetic enolates derived from unsym. cyclic ketones, cyclohexenones, and certain methyl ketones was achieved. Acyloin regioisomers are not interconverted under the reaction conditions. Hydroxylation of nonhindered ketones is complicated by aldol condensation between unreacted enolate and the oxidation intermediate. This problem was minimized by reaction in dilute solution, or by using an inverse addition technique (enolate added to I). Oxidation of enolate analogs prepared from oximes or N,N-dimethylhydrazones has been demonstrated, although yields were low. Stabilized enolates of 1,3-dicarbonyl compounds were not hydroxylated and the related dianions afforded complex product mixtures In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0SDS of cas: 15399-05-0).
Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.SDS of cas: 15399-05-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics