Extraction, chemical composition, and anticancer potential of Origanum onites L. essential oil was written by Spyridopoulou, Katerina;Fitsiou, Eleni;Bouloukosta, Eleni;Tiptiri-Kourpeti, Angeliki;Vamvakias, Manolis;Oreopoulou, Antigoni;Papavassilopoulou, Eleni;Pappa, Aglaia;Chlichlia, Katerina. And the article was included in Molecules in 2019.Computed Properties of C6H12O2 This article mentions the following:
Origanum species are plants rich in volatile oils that are mainly used for culinary purposes. In recent years, there has been a growing interest in the biol. activities of their essential oils. Origanum onites L. is a plant mainly found in Greece, Turkey, and Sicily, whose oil is rich in carvacrol, a highly bioactive phytochem. The aim of this study was to analyze the chem. composition of Origanum onites essential oil (OOEO), and investigate its potential anticancer effects in vitro and in vivo. GC/MS anal. identified carvacrol as OOEO’s main constituent. In vitro antiproliferative activity was assayed with the sulforhodamine B (SRB) assay against human cancer cell lines from four tumor types. HT-29, a colorectal cancer cell line, was the most sensitive to the antiproliferative activity of OOEO. Wound-healing assay and Annexin V-PI staining were employed to investigate the antimigratory and the pro-apoptotic potential of OOEO, resp., against human (HT-29) and murine (CT26) colon cancer cells. Notably, OOEO attenuated migration and induced apoptosis-related morphol. changes in both cell lines. Prophylactic oral administration of the oil in a BALB/c exptl. mouse model inhibited the growth of syngeneic CT26 colon tumors. As far as we know, this is the first report on the antitumor potential of orally administered OOEO. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Computed Properties of C6H12O2).
Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C6H12O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics