Synthesis of 1,1-[1-Naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their Evaluation as Inhibitors of Serotonin, Norepinephrine, and Dopamine Transporters was written by White, James D.;Juniku, Rajan;Huang, Kun;Yang, Jongtae;Wong, David T.. And the article was included in Journal of Medicinal Chemistry in 2009.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:
Stereodefined trisubstituted cyclopropanes I bearing naphthyloxy, thiophenyl, and (N-methylamino)methyl groups were synthesized in enantiopure form employing asym. cyclopropanation of (E)- and (Z)-allylic alcs. as the key step. In vitro assays of the synthesized cyclopropanes revealed that the Ki of one of the enantiomers as a dual inhibitor of serotonin and norepinephrine transporters is in the low nanomolar range and is comparable to that of duloxetine. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).
Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics