Enantiomer separation of mandelates and their analogs on cyclodextrin derivative chiral stationary phases by capillary GC was written by Nie, Meng-Yan;Zhou, Liang-Mo;Wang, Qing-Hai;Zhu, Dao-Qian. And the article was included in Analytical Sciences in 2001.Related Products of 15399-05-0 This article mentions the following:
Enantiomer separation of mandelates and their analogs, which are important intermediates in asym. synthetic and pharmaceutical chem., was studied by capillary gas chromatog. using different cyclodextrin derivative chiral stationary phases (CD CSPs). The used cyclodextrin derivatives included permethylated 灏?CD (PMBCD), permethylated 绾?CD, heptakis(2,6-di-O-butyl-3-O-butyryl)-灏?CD, heptakis(2,6-di-O-pentyl-3-O-acetyl)-灏?CD and heptakis(2,6-di-O-nonyl-3-O-trifluoroacetyl)-灏?CD (DNTBCD), resp. Among all the CSPs used, PMBCD and DNTBCD exhibited the broadest and best enantioselectivity for all the racemates studied. Some thermodn. parameters were evaluated and an enthalpy-entropy compensation effect was observed in enantiomer separation processes of mandelates and their analogs. Based on thermodn. data and mol. mechanics calculations, the chiral recognition mechanism of mandelate derivatives on CD CSPs is discussed. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Related Products of 15399-05-0).
Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 15399-05-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics