In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 454-31-9, name is Ethyl 2,2-difluoroacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of Ethyl 2,2-difluoroacetate
0 g of (1R,2S)-2-amino-1-(4-chlorophenyl)-3-fluoropropan-1-ol was dissolved in 350ml_ methanol, and then 5g of triethyl amine and 30.5g of ethyl difluoroacetate were added and stirred for 12 hours at room temperature. The solvent was evaporated off under reduced pressure, and the residue was recrystallized in isopropanol and water to obtain 12.7g of a white solid (yield 92%).
The synthetic route of 454-31-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZOETIS SERVICES LLC.; DEJONG, Randall Lee; KARRICK, Gregory Lee; STUK, Timothy Lee; (56 pag.)WO2020/68607; (2020); A1;,
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