Reformatsky and Blaise reactions in flow as a tool for drug discovery: one pot diversity oriented synthesis of valuable intermediates and heterocycles was written by Huck, L.;Berton, M.;de la Hoz, A.;Diaz-Ortiz, A.;Alcazar, J.. And the article was included in Green Chemistry in 2017.Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:
The application of Reformatskii and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles, e.g., I in a one-pot protocol was described. To achieve this goal, a greener activation protocol for zinc in flow conditions was developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).
Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics