Synthesis and biological evaluation of 3-substituted-indolin-2-one derivatives containing chloropyrrole moieties was written by Jin, Yun-Zhou;Fu, Da-Xu;Ma, Nan;Li, Zhan-Cheng;Liu, Quan-Hai;Xiao, Lin;Zhang, Rong-Hua. And the article was included in Molecules in 2011.Category: esters-buliding-blocks This article mentions the following:
Novel 3-substituted indolin-2-ones containing chloropyrroles were synthesized and their biol. activities were evaluated. The presence of Cl on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethylamino)ethylcarbamoyl group as a substituent at C(4′) of the pyrrole enhanced the antitumor activities notably. IC50 values of 0.32, 0.67, 1.19, and 1.22 μM were achieved against non-small cell lung cancer (A549), oral epithelial (KB), melanoma (K111), and large cell lung cancer cell lines (NCI-H460), resp. In the experiment, the researchers used many compounds, for example, Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7Category: esters-buliding-blocks).
Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics