Electrochemical Synthesis of 1-Naphthols by Intermolecular Annulation of Alkynes with 1,3-Dicarbonyl Compounds was written by He, Mu-Xue;Mo, Zu-Yu;Wang, Zi-Qiang;Cheng, Shi-Yan;Xie, Ren-Ren;Tang, Hai-Tao;Pan, Ying-Ming. And the article was included in Organic Letters in 2020.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:
C-centered radical cyclization under electrochem. conditions is a feasible strategy for constructing cyclic structures. Reported herein is the electrochem. synthesis of highly functionalized 1-naphthols using alkynes and 1,3-dicarbonyl compounds by (4 + 2) annulation of C-centered radical. Electrolysis was conducted with Cp2Fe as redox catalyst, thereby eliminating the use of oxidants and transition-metal catalysts. The synthesized 1-naphthol compounds showed good antitumor activity in vitro, and further studies indicated that compound I induced tumor cell apoptosis. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).
Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics