Solution-Phase Parallel Synthesis of Spirohydantoins was written by Nieto, Marcelo J.;Philip, Ashok E.;Poupaert, Jacques H.;McCurdy, Christopher R.. And the article was included in Journal of Combinatorial Chemistry in 2005.COA of Formula: C8H4N2O This article mentions the following:
Spirohydantoins are considered privileged structures, making them attractive for the preparation of compound libraries with the potential for diverse biol. activity. However, very few modifications of this scaffold have been reported to date. The spirohydantoin template was elaborated into a library of 168 compounds through a two-step solution-phase parallel synthesis starting from various N-substituted piperidinone derivatives The Strecker reaction was employed to generate α-amino nitriles from aniline and TMSCN (or KCN). Subsequent reaction of the anilido nitrogen with a diverse set of isocyanates, followed by refluxing under acidic conditions, afforded the title library in high yield and purity. An example compound thus prepared was 3-butyl-8-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decane-2,4-dione (I). In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6COA of Formula: C8H4N2O).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C8H4N2O
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics