A metal-free desulfurizing radical reductive C-C coupling of thiols and alkenes was written by Qin, Qixue;Wang, Weijing;Zhang, Cheng;Song, Song;Jiao, Ning. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Application In Synthesis of Methyl 4-(2-hydroxyphenyl)butanoate This article mentions the following:
An intermol. reductive C-C coupling of electrophilic alkyl radicals and alkenes was developed. Thiols were used as both hydrogen-donating reagents and alkyl radical precursors in the presence of tri-Et phosphite and radical initiator. A wide range of alkenes, including styrenes and aliphatic olefins were well tolerated in this transformation. Mechanistic studies indicated that a phosphite promoted radical desulfurization of thiols to accessed electrophilic alkyl radicals and a radical chain propagation process may be involved in this transformation. In the experiment, the researchers used many compounds, for example, Methyl 4-(2-hydroxyphenyl)butanoate (cas: 93108-07-7Application In Synthesis of Methyl 4-(2-hydroxyphenyl)butanoate).
Methyl 4-(2-hydroxyphenyl)butanoate (cas: 93108-07-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application In Synthesis of Methyl 4-(2-hydroxyphenyl)butanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics