(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.HPLC of Formula: 87694-53-9
Effect of the CH2NH and CH2NAc peptide bond isosteres on the antagonistic and histamine releasing activities of a luteinizing hormone-releasing hormone analog was written by Hocart, Simon J.;Nekola, Mary V.;Coy, David H.. And the article was included in Journal of Medicinal Chemistry in 1988.HPLC of Formula: 87694-53-9 This article mentions the following:
The effect of the CH2NH and CH2NAc peptide bond isosteres on the antagonistic and histamine releasing activities of the LH-RH antagonist [N-Ac-D-Nal1,D-Phe2,3,D-Arg6,Phe7,D-Ala10]LH-RH [Nal = 3-(2-naphthyl)alanine] was investigated. The moieties introduced by facile, racemization-free solid-phase synthesis in an attempt to reduce the histamine releasing activity inherent to the most potent analogs while retaining high antiovulatory activity. The ψ(CH2NH] isostere was incorporated at each CONH site with the exception of 8-9, which involves proline, by reductive alkylation with a protected amino acid aldehyde in the presence of NaBH3CN during conventional solid-phase peptide synthesis. The ψ[CH2NH] group was extremely resistant to derivatization and could only be partially acetylated to give ψ[CH2NAc]. The analogs were cleaved from the resin with simultaneous deprotection by anhydrous HF and purified to homogeneity in 2 stages: gel permeation followed by preparative reversed-phase liquid chromatog. The analogs were assayed in standard rat antiovulatory and in vitro histamine release assays. The isosteres caused a loss of the antiovulatory activity of the antagonist at the 50-μg dose when incorporated at the positions 1-2, 2-3, 3-4, and 7-8. Incorporation at the other positions resulted in a less marked reduction in activity relative to the unmodified parent analog. No significant effect was noted on the potent histamine releasing activity of the analogs. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9HPLC of Formula: 87694-53-9).
(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.HPLC of Formula: 87694-53-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics