Nickel-Catalyzed C-H Trifluoromethylation of Electron-Rich Heteroarenes was written by Wu, Yun;Zhang, Hao-Ran;Jin, Ruo-Xing;Lan, Quan;Wang, Xi-Sheng. And the article was included in Advanced Synthesis & Catalysis in 2016.Name: Ethyl 4-methyl-1H-pyrrole-3-carboxylate This article mentions the following:
The first example of a nickel-catalyzed C-H trifluoromethylation of electron-rich heteroarenes, including imidazopyridines, indoles and thiophenes, has been developed with the com. available and relatively inexpensive industrial raw material iodotrifluoromethane (CF3I) as the trifluoromethylating reagent. The synthetic potential of this method is demonstrated by its successful application to the direct trifluoromethylation of the biol. active mols. melatonin and zolmitriptan. In the experiment, the researchers used many compounds, for example, Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7Name: Ethyl 4-methyl-1H-pyrrole-3-carboxylate).
Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Name: Ethyl 4-methyl-1H-pyrrole-3-carboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics