Synthesis of α,ω-difunctional long-chain n-alkanes. I. Coupling of ω-functionalized acid chlorides by triethylamine was written by Zantour, Hedi;Pousse, Andre;Brini, Mathilde. And the article was included in Bulletin de la Societe Chimique de France in 1972.Application In Synthesis of 12-Methoxy-12-oxododecanoic acid This article mentions the following:
Ten difunctional ketones R (CH2)n-CO(CH2)nR (n = 6,8,10,15,16, 22 R = OMe, CN, Br, CH:CH2, C:O2H) are prepared by coupling of the corresponding R(CH2)n-COCl in the presence of Et3N. Β-Lactones (I) are intermediates which are isolated. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Application In Synthesis of 12-Methoxy-12-oxododecanoic acid).
12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of 12-Methoxy-12-oxododecanoic acid
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics