Detours en route to a total synthesis of (+)-cassiol was written by Colombo, Maria I.;Zinczuk, Juan;Bohn, Maria L.;Ruveda, Edmundo A.. And the article was included in Tetrahedron: Asymmetry in 2003.Category: esters-buliding-blocks This article mentions the following:
A synthesis of the antiulcerogenic compound (+)-cassiol was achieved in 43% yield starting with lactol (S)-I and sulfone II. This short and efficient synthesis features the one-pot Julia olefination reaction of the sodium anion of (S)-I with II, through the key intermediate (-)-III. This synthesis has been developed as a result of exploratory experiments including different olefination reactions on I. An attempt to synthesize the intermediate III by an intramol. aldol condensation approach of the open chain precursor is also described. In the experiment, the researchers used many compounds, for example, Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7Category: esters-buliding-blocks).
Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics