Synthesis and evaluation of the anticoccidial activity of trifluoropyrido[1,2-a]pyrimidin-2-one derivatives was written by Silpa, Laurence;Niepceron, Alisson;Laurent, Fabrice;Brossier, Fabien;Penichon, Melanie;Enguehard-Gueiffier, Cecile;Abarbri, Mohamed;Silvestre, Anne;Petrignet, Julien. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Formula: C7H8N2O2 This article mentions the following:
Trifluoromethylpyridopyrimidinones such as I (R = H, Br, Cl, I, Ph, 4-MeOC6H4, 4-FC6H4; R1 = H, Cl, I; R2 = H, Br, I, O2N, MeO2C, NC, Me, Ph, 4-MeOC6H4, 4-FC6H4) were prepared by cyclocondensation reactions of aminopyridines with Et 4,4,4-trifluoro-2-butynoate and tested for their anticoccidial activity (the inhibition of bovine kidney cell invasion by Eimeria tenella). The in vitro anticoccidial activities and toxicities to bovine kidney cells of I (R = Cl, Br, I; R1 = H, Cl, I; R2 = H, Br) were determined Screening of a chem. library to discover new mols. exhibiting in vitro activity against the invasion of host cells by Eimeria tenella yielded the lead compound I (R = I; R1 = H; R2 = Br) with an IC50 of 15 μM. Four compounds I (R = Cl, Br, I; R1 = H, Cl, I; R2 = H, Br) inhibited Eimeria tenella invasion with IC50 values of 0.8-3.8 μM, better than the initial lead compound In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Formula: C7H8N2O2).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C7H8N2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics