Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors was written by El-Adl, Khaled;El-Helby, Abdel-Ghany A.;Ayyad, Rezk R.;Mahdy, Hazem A.;Khalifa, Mohamed M.;Elnagar, Hamdy A.;Mehany, Ahmed B. M.;Metwaly, Ahmed M.;Elhendawy, Mostafa A.;Radwan, Mohamed M.;ElSohly, Mahmoud A.;Eissa, Ibrahim H.. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Related Products of 118-61-6 This article mentions the following:
Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer. Thus, nineteen new quinazoline-4(3H)-one derivatives were designed and synthesized. Preliminary cytotoxicity studies of the synthesized compounds were evaluated against three human cancer cell lines (HepG-2, MCF-7 and HCT-116) using MTT assay method. Doxorubicin and sorafenib were used as pos. controls. Five compounds were found to have promising cytotoxic activities against all cell lines. Compound 16f, containing a 2-chloro-5-nitrophenyl group, has emerged as the most active member. It was approx. 4.39-, 5.73- and 1.96-fold more active than doxorubicin and 3.88-, 5.59- and 1.84-fold more active than sorafenib against HepG2, HCT-116 and MCF-7 cells, resp. The most active cytotoxic agents were further evaluated in vitro for their VEGFR-2 inhibitory activities. The results of in vitro VEGFR-2 inhibition were consistent with that of the cytotoxicity data. Mol. docking of these compounds into the kinase domain, moreover, supported the results. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Related Products of 118-61-6).
Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 118-61-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics