These common heterocyclic compound, 4341-76-8, name is Ethyl 2-butynoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C6H8O2
Compound A (ethyl 2-butynoate, 1.12 g, 10 mmol) was dissolved in tetrahydrofuran.Add N,O-dimethylhydroxylamine hydrochloride (1.94 g, 20 mmol),Cool to -40 C,Isopropylmagnesium chloride (2M/L, 15 mL, 30 mmol) was added and reacted for 1 h.The reaction was completed, quenched with water, ethyl acetate (200 mL¡Á3), and brine (100 mL¡Á6)Concentrated under reduced pressure and purified by silica gel column chromatographyCompound B (colorless oil, 1.15 g, 91%).
The synthetic route of Ethyl 2-butynoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lanzhou University; Tu Yongqiang; Zhang Qing; (20 pag.)CN109666030; (2019); A;,
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