Multifunctional poly(amine-ester)-type hyperbranched polymers: lipase-catalyzed green synthesis, characterization, biocompatibility, drug loading and anticancer activity was written by Xu, Fangli;Zhong, Jiaren;Qian, Xueqi;Li, Yanyan;Lin, Xianfu;Wu, Qi. And the article was included in Polymer Chemistry in 2013.Recommanded Product: Dimethyl decanedioate This article mentions the following:
Hyperbranched polymers (HBPs) have attracted more and more attention because of their specially branched architecture and interesting properties. A series of novel poly(amine-ester)-type HBPs were synthesized through CALB-catalyzed polycondensation between triethanolamine (TEOA) and diesters after the optimization of reaction conditions. The precise structure including degree of branching, components percentage, and the controllable terminal structures at the outer surface were determined by FTIR, 1H NMR, 13C NMR, 2D NMR and GPC. The interesting multifunctionality displayed by the poly(amine-ester)-type HBPs was investigated. These HBPs could be degraded efficiently under the catalysis of lipase in weak acid buffer. The amphiphilic HBPs with hydroxyl terminals were able to form multimol. micelles with 250-400 nm diameter, and 0.042 g L-1 CMC. They were nontoxic to COS-7 cells, while they could effectively inhibit the growth of cancer cells HepG2 with IC50 of 130 μg mL-1 after an anticancer drug was encapsulated within the micelles. All these results indicated the prepared poly(amine-ester)-type HBPs can serve as multifunctional biomaterials for biomedical applications. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Recommanded Product: Dimethyl decanedioate).
Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Dimethyl decanedioate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics