Search for new pharmacophores for antimalarial activity. Part I: Synthesis and antimalarial activity of new 2-methyl-6-ureido-4-quinolinamides was written by Madapa, S.;Tusi, Z.;Sridhar, D.;Kumar, A.;Siddiqi, M. I.;Srivastava, K.;Rizvi, A.;Tripathi, R.;Puri, S. K.;Shiva Keshava, G. B.;Shukla, P. K.;Batra, S.. And the article was included in Bioorganic & Medicinal Chemistry in 2009.Product Details of 16413-26-6 This article mentions the following:
A total of 80 new 2-methyl-6-ureido-4-quinolinamides were synthesized and evaluated for their antimalarial activity. Several analogs elicited the antimalarial effect at MIC of 0.25 mg/mL against the chlooquine-sensitive P. falciparum strain. The IC50 values of the active compounds were observed to be in ng/mL range and two of the analogs have better IC50 value than the standard chloroquine. In the in vivo assay against mdr CQ resistant P. yoelii N67/P. yoelii nigeriensis, however, none of the compound showed complete suppression of parasitemia on day 7. One of the compounds displayed significant antibacterial effect against several strains of bacteria and was many-fold better than the standard drug gentamicin. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Product Details of 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 16413-26-6
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics