Hagishita, Sanji et al. published their research in Bioorganic & Medicinal Chemistry in 1997 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 16413-26-6

Synthesis and pharmacological properties of ureidomethylcarbamoylphenylketone derivatives. A new potent and subtype-selective nonpeptide CCK-B/gastrin receptor antagonist, S-0509 was written by Hagishita, Sanji;Murakami, Yosushi;Seno, Kaoru;Kamata, Susumu;Haga, Nobuhiro;Konoike, Toshiro;Kanda, Yasuhiko;Kiyama, Ryuichi;Shiota, Takeshi;Ishihara, Yasunobu;Ishikawa, Michio;Shimamura, Mayumi;Abe, Koji;Yoshimura, Koji. And the article was included in Bioorganic & Medicinal Chemistry in 1997.Recommanded Product: 16413-26-6 This article mentions the following:

A novel series of CCK-B/gastrin receptor antagonists-ureidomethylcarbamoylphenylketone derivatives-were designed, synthesized, and evaluated for activity. Structure-activity relationship studies revealed the importance of a carboxylic acid at substituent R2 and a tert-butoxycarbonyl group at R1 in structure A. Ureidomethylcarbamoylphenylketone PhCO-2-C6H4N(CH2CO2CMe3)COCH2NHCONHC6H4-3-CO2H (I) (S-0509) showed remarkable affinity for the CCK-B/gastrin receptor and a subtype selectivity profile in vitro. Administration (id) of I led to excellent inhibition of gastric acid secretion induced by pentagastrin in anesthetized rats with an ED50 value of 0.014 mg/kg. Furthermore, I proved to have poor blood-brain permeability by its small effect on enhancement of morphine analgesia. Thus, I has an increase in selectivity for the peripheral effects of gastrin antagonism from the central effects of CCK-B antagonism. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics