Dithioesters: simple, tunable, cysteine-selective H2S donors was written by Cerda, Matthew M.;Newton, Turner D.;Zhao, Yu;Collins, Brylee K.;Hendon, Christopher H.;Pluth, Michael D.. And the article was included in Chemical Science in 2019.Electric Literature of C14H12S2 This article mentions the following:
Dithioesters have a rich history in polymer chem. for RAFT polymerizations and are readily accessible through different synthetic methods. Here we demonstrate that the dithioester functional group is a tunable motif that releases H2S upon reaction with cysteine and that structural and electronic modifications enable the rate of cysteine-mediated H2S release to be modified. In addition, we use (bis)phenyl dithioester to carry out kinetic and mechanistic investigations, which demonstrate that the initial attack by cysteine is the rate-limiting step of the reaction. These insights are further supported by complementary DFT calculations We anticipate that the results from these investigations will allow for the further development of dithioesters as important chem. motifs for studying H2S chem. biol. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Electric Literature of C14H12S2).
Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C14H12S2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics