Synthesis, characterization and antimicrobial activity of azetidine derivatives was written by Choudhary, Shweta;Dubey, Archana;Chaturvedi, Prerna;Birle, Rekha. And the article was included in International Journal of Pharmacy and Life Sciences in 2021.Recommanded Product: Ethyl 2-hydroxybenzoate This article mentions the following:
In present study azetidine derivatives were synthesized and microbial activity of different derivatives were checked with various microbial stain. Various intermediates was synthesized and characterized in between time to time by chromatog. and special methods. Substituted salicylic acid and sulfuric acid were starting material and finally formed2-Hydroxy -N-2-oxa-4-phenylazet-1(2H)0ylbenzamide(D), while in the intermediate steps(A) Ethylsalicylate react with hydrazine hydrate to get,(B) Salicyl Hydrazide, and this (B) compound reflux with sulfuric acid to get (C) 2 -hydroxy-N-[(Z)- phenylmethylidene]benzohydrazide. Azetidine derivatives have been synthesized from Schiff base of the corresponding hydrazine by using ethanol with reflex. The structure of the entire synthesized compound was established on the basis of element, chromatog. and spectral anal. The synthesized compound was evaluated for their antimicrobial activity. Most active be against Staphylococcus. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Recommanded Product: Ethyl 2-hydroxybenzoate).
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Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics