Development of selective tight-binding inhibitors of leukotriene A4 hydrolase was written by Yuan, Wei;Munoz, Benito;Wong, Chi Huey;Haeggstroem, Jesper Z.;Wetterholm, Anders;Samuelsson, Bengt. And the article was included in Journal of Medicinal Chemistry in 1993.Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:
A systematic study on the enzyme specificity and the inhibition of leukotriene A4 hydrolase amidase activity with more than 30 synthetic inhibitors has led to the development of α-keto-β-amino ester I (R = COCO2CH2Ph) and thioamine I (R = CH2SH) as tight-binding, competitive type transition-state analog inhibitors of the aminopeptidase activity, with Ki values of 46 and 18 nM, resp. Both compounds also inhibit the epoxide hydrolase activity, with the IC50 values of 1 μM and 0.1 μM, resp. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).
(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics