Design, synthesis, and biological evaluation of imidazo [1,2-a] pyridine derivatives as acetylcholinesterase inhibitors was written by Boppana, Sriramamurthy;Ahmed, Faiyaz;Chandra, Narendra Sharath J. N.;Rangappa, Kanchugarakoppal S.;Urooj, Asna. And the article was included in Journal of Pharmacy Research in 2010.Recommanded Product: Methyl 2-aminonicotinate This article mentions the following:
To explore novel and effective drugs for the treatment of Alzheimers disease(AD), a series of inhibitors of acetylcholinesterase (AChE) were designed based on the Structure-based generation of a novel series of AchE inhibitors were carried out with crystal structure of acetylcholine esterase complexed with choline (PDB: 2HA3) obtained from protein data. Among synthesized inhibitor 7(a-e) exhibited good potency in enzyme inhibitory potency AChE: IC= 55 ± 0.53M, 73 ± 0.37M, and 51 ± 0.37M, 73 ± 0.40M, 48±0.75M, 7b and 7C also showed moderate to good activity in acetylcholinesterase assay in vitro using different sources of acetylcholinesterase studied (rat brain, human serum and elec. eel). In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Recommanded Product: Methyl 2-aminonicotinate).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 2-aminonicotinate
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