Yale, Harry L. et al. published their research in Journal of Heterocyclic Chemistry in 1976 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Related Products of 14667-47-1

Tetrahydro- and octahydropyrido[1,2-a]pyrimidin-4-ones was written by Yale, Harry L.;Spitzmiller, Ervin R.. And the article was included in Journal of Heterocyclic Chemistry in 1976.Related Products of 14667-47-1 This article mentions the following:

The catalytic hydrogenation of the pyridopyrimidines I [R = Me, Pr, Ph; R1 = H, Me; R2 = 9-Me, 8-Me, 9-HO; R = Me, R1 = H, R2 = 9-CO2H, 9-CO2Et, 9-CONH2, 9-CONHMe, 9-CO2Me, 9-CONH(CH2)3NMe2] gave II and fully saturated, octahydro analogs. In the PMR spectra of II [R = Me, R1 = H, R2 = 9-CO2H, 9-CO2Et, 9-CO2Me, 9-CONH2, 9-CONHMe, CONH(CH2)3NMe2] there was evidence of a facile 1,3-prototropic shift of the proton from position-9 to position-1, resulting in equilibrium between tautomeric species. The ratio of tautomers present at equilibrium, with the esters, favored the enamine conformation, but with both the carboxylic acid and the amides the imine structure predominated. Supportive evidence for the enamine structure with the esters was derived also from the ir spectra. Alkylation of the anion derived from the tetrahydro 9-carbomethoxy derivative with NaH led exclusively to derivatives of the 6,7,8,9-tetrahydro system. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Related Products of 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Related Products of 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics