Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease was written by Harrison, Justin R.;Sarkar, Sandipan;Hampton, Shahienaz;Riley, Jennifer;Stojanovski, Laste;Sahlberg, Christer;Appelqvist, Pia;Erath, Jessey;Mathan, Vinodhini;Rodriguez, Ana;Kaiser, Marcel;Pacanowska, Dolores Gonzalez;Read, Kevin D.;Johansson, Nils Gunnar;Gilbert, Ian H.. And the article was included in Journal of Medicinal Chemistry in 2020.Product Details of 14667-47-1 This article mentions the following:
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Chagas disease is not satisfactory, and there is a need for new treatments. In this work, we describe the optimization of a hit compound resulting from the phenotypic screen of a library of compounds against T. cruzi. The compound series was optimized to the level where it had satisfactory pharmacokinetics to allow an efficacy study in a mouse model of Chagas disease. We were able to demonstrate efficacy in this model, although further work is required to improve the potency and selectivity of this series. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Product Details of 14667-47-1).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 14667-47-1
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics