DNA base pair-specific ligands. I. Synthesis of distamycin A and its analogs with different numbers of N-methyl-and N-propylpyrrole residues was written by Grokhovskii, S. L.;Zhuze, A. L.;Gottikh, B. P.. And the article was included in Bioorganicheskaya Khimiya in 1975.Reference of 5930-92-7 This article mentions the following:
Distamycin A (I, R = Me) and its structural analogs I (R = Pr), II (R = Me, Pr), and III (R = Me, Pr) were obtained from Et 4-nitropyrrole-2-carboxylate by alkylation, saponification, chlorination, treatment with H2NCH2CH2CN, and hydrogenation. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7Reference of 5930-92-7).
Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Reference of 5930-92-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics