Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity was written by Yang, Yifei;Zhang, Yuan;Yang, Ling Yun;Zhao, Leilei;Si, Lianghui;Zhang, Huibin;Liu, Qingsong;Zhou, Jinpei. And the article was included in Bioorganic Chemistry in 2017.Recommanded Product: 14667-47-1 This article mentions the following:
Receptor tyrosine kinase c-Met acts as an alternative angiogenic pathway in the process and contents of cancers. A series of imidazopyridine derivatives were designed and synthesized according to the established docking studies as possible c-Met inhibitors. Most of these imidazopyridine derivatives displayed nanomolar potency against c-Met in both biochem. enzymic screens and cellular pharmacol. studies. Especially, compound 7 g exhibited the most inhibitory activity against c-Met with IC50 of 53.4 nM and 253 nM in enzymic and cellular level, resp. Following that, the compound 7 g was docked into the protein of c-Met and the structure-activity relationship was analyzed in detail. These findings indicated that the novel imidazopyridine derivative compound 7 g was a potential c-Met inhibitor deserving further investigation for cancer treatment. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Recommanded Product: 14667-47-1).
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