Silica gel chemically bonded with polyacrylamide via thiol-ene click chemistry as stationary phase material for hydrophilic interaction liquid chromatography was written by Yang, Duo;Yu, Dong-ping;Dong, Xue-fang;Shen, Ai-jin;Jin, Gao-wa;Guo, Zhi-mou;Yan, Jing-yu;Liu, Ming-yang;Liang, Xin-miao. And the article was included in Fenxi Huaxue in 2015.Computed Properties of C14H12S2 This article mentions the following:
Thiol-ene click chem. was applied to immobilize poly-acrylamide onto thiol-modified silica gel to prepare a novel stationary phase for hydrophilic interaction liquid chromatog. Polymer was synthesized by reversible addition-fragmentation chain transfer reaction of acrylamide and benzyl benzodithioate. Alkenyl functionalities were introduced onto the silica gel by the reaction of 3-isocyanatopropyltrimethoxysilane, allylamine and pyridine in toluene, and then the product was reacted with silica gel. The thiol-modified silica gel reacted with the poly-acrylamide prepared in methanol at 55°C for 48 h in the presence of 2,2-azo two iso-Bu amidine hydrochloride to give a novel stationary phase for hydrophilic interaction liquid chromatog. By using characterization method of elemental anal. and IR spectroscopy, compared with ethylene urea silica (EUS), the carbon content increased, and multiple amide IR characteristic peaks existed at 1636 cm-1 and 1570 cm-1. The effects of water content, salt concentration and pH of mobile phase on the retention time of polar compound were investigated. The results showed that with the increase of water content, retention time decreased; neural and basic compounds increases with the increasing salt concentration; and basic compounds decreased with the decrease of pH in the pH 3.3-4.8 range, which were both in contrast with the acid compounds The better successful separation of nucleosides and glycosides was obtained by the novel stationary phase compared with traditional stationary phase of silica gel, illustrating great potential of the stationary phase in the separation of polar compounds In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Computed Properties of C14H12S2).
Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C14H12S2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics