Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans was written by Kulikov, A. S.;Epishina, M. A.;Batog, L. V.;Rozhkov, V. Yu.;Makhova, N. N.;Konyushkin, L. D.;Semenova, M. N.;Semenov, V. V.. And the article was included in Russian Chemical Bulletin in 2013.Recommanded Product: 13669-10-8 This article mentions the following:
A method of 3-amino-4-[5-aryl(heteroaryl)-1H-1,2,3-triazol-1-yl]furazan synthesis was optimized. Condensation of these compounds with 2,5-dimethoxytetrahydrofuran resulted in a series of novel 4-[5-aryl(heteroaryl)-1H-1,2,3-triazol-1-yl]-3-(pyrrol-1-yl)furazans. All target compounds were evaluated for both antimitotic microtubule destabilizing in a phenotypic sea urchin embryo assay and cytotoxicity in human cancer cell lines. The pyrrolyl derivatives of triazolylfurazans were determined as antiproliferative compounds The most potent microtubule targeting compounds, 4-[5-(4-methoxyphenyl)- and -5-(4-ethoxyphenyl)-1H-1,2,3-triazol-1-yl]-3-(pyrrol-1-yl)furazan showed potential as antineoplastic agents. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).
Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 13669-10-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics