Solvent selection for extractive distillation processes to separate close-boiling polar systems was written by Sprakel, Lisette M. J.;Kamphuis, Peter;Nikolova, Anna L.;Keijsper, Dylan J.;Schuur, Boelo. And the article was included in Chemical Engineering Research and Design in 2019.Recommanded Product: Methyl2-methylbutyrate This article mentions the following:
Solvent selection is key in extractive distillation process development and solvent effects are often predicted based on the activity coefficients at infinite dilution For close-boiling polar systems with strong or specific interacting species, standard simulation tools, e.g. using UNIFAC or COSMO-RS, often predict poor as the activity coefficients at infinite dilution not always reflect the selectivity in the process. For these systems, a heuristic solvent selection method in which mol. properties such as acidity, hydrogen bonding and polarity are applied is desired as first estimate in the solvent selection. To explore the key parameters for such a first selection, solvent effects on the relative volatility (α) were measured for three different industrially relevant polar mixtures, valeric acid – 2-methylbutyric acid, diethylmethylamine – diisopropylether, and 2-butanol – 2-butanone. For each of the cases the effect of potential solvents on α was measured in an ebulliometer. For the acids, the difference in pKa of 0.1 was too small to sep. based on acidity with a moderately basic solvent. Stronger basic solvents resulted in thermal and chem. instability. Although the solvent methyl-2-Me butyrate is not suitable as a solvent because of reactivity, this structurally similar solvent showed selectivity, indicating also in extractive distillation the like dissolves like phenomenon can be applied to induce selectivity. A larger difference in basicity of the mixture components (amine-ether mixture) and a difference in hydrogen bonding affinity between the mixture components (ketone-alc. mixture) allowed for increasing α based on differences in acidity and hydrogen bonding, resp. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Recommanded Product: Methyl2-methylbutyrate).
Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: Methyl2-methylbutyrate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics