Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors was written by Corbett, J. W.;Dirico, K.;Song, W.;Boscoe, B. P.;Doran, S. D.;Boyer, D.;Qiu, X.;Ammirati, M.;VanVolkenburg, M. A.;McPherson, R. K.;Parker, J. C.;Cox, E. D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Electric Literature of C9H9FO2 This article mentions the following:
The cis-3-amino-4-(2-cyanopyrrolidide)-pyrrolidine template has been shown to afford low nanomolar inhibitors of human DPP-IV that exhibit a robust PK/PD profile. An X-ray co-crystal structure of I confirmed the proposed mode of binding. The potent single digit DPP-IV inhibitor II exhibited a preferred PK/PD profile in preclin. animal models and was selected for addnl. profiling. In the experiment, the researchers used many compounds, for example, Methyl 4-fluoro-3-methylbenzoate (cas: 180636-50-4Electric Literature of C9H9FO2).
Methyl 4-fluoro-3-methylbenzoate (cas: 180636-50-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C9H9FO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics