T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis was written by Smith, Elizabeth M.;Sorota, Steve;Kim, Hyunjin M.;McKittrick, Brian A.;Nechuta, Terry L.;Bennett, Chad;Knutson, Chad;Burnett, Duane A.;Kieselgof, Jane;Tan, Zheng;Rindgen, Diane;Bridal, Terry;Zhou, Xiaoping;Jia, Yu-Ping;Dong, Zoe;Mullins, Debbie;Zhang, Xiaoping;Priestley, Tony;Correll, Craig C.;Tulshian, Deen;Czarniecki, Michael;Greenlee, William J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Category: esters-buliding-blocks This article mentions the following:
A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (CaV3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and optimization of the potency, selectivity and DMPK properties of leads will be described. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Category: esters-buliding-blocks).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics