1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents was written by Epstein, Joseph W.;Brabander, Herbert J.;Fanshawe, William J.;Hofmann, Corris M.;McKenzie, Thomas C.;Safir, Sidney R.;Osterberg, Arnold C.;Cosulich, D. B.;Lovell, F. M.. And the article was included in Journal of Medicinal Chemistry in 1981.Recommanded Product: Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:
The title analgesics I (R = organo substituent) were prepared by insertion reaction of RC6H4CHBrCO2R with acrylate esters followed by cyclocondensation of the resultant cyclopropanedicarboxylic acid derivatives with urea, than reduction of the resultant amides. The more potent I are the para-substituted derivatives In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Recommanded Product: Ethyl 2-(4-fluorophenyl)acetate).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Ethyl 2-(4-fluorophenyl)acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics