Structure-activity Relationship Studies of Microbiologically Active Thiosemicarbazides Derived from Hydroxybenzoic Acid Hydrazides was written by Plech, Tomasz;Paneth, Agata;Kapron, Barbara;Kosikowska, Urszula;Malm, Anna;Strzelczyk, Aleksandra;Staczek, Pawel. And the article was included in Chemical Biology & Drug Design in 2015.Category: esters-buliding-blocks This article mentions the following:
Forty-five derivatives of thiosemicarbazide were synthesized, and their antibacterial activity against Gram-pos. and Gram-neg. bacteria was evaluated. Some of the described compounds exhibited interesting activity against reference strains of Gram-pos. bacteria, whereas only two derivatives had the ability to inhibit the growth of Gram-neg. species (Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, Proteus mirabilis ATCC 12453). The most potent antimicrobial activity was observed in the cases of salicylic acid hydrazide derivatives The differences in activity inspired us to conduct conformational anal. using mol. mechanics level. The obtained results suggest that the mol. geometry, especially at the N4-terminus of thiosemicarbazide skeleton, determines the antibacterial activity. Unfortunately, in opposition to what we expected, only one of the tested compounds inhibited the activity of the topoIV enzyme, and none of them was active against DNA gyrase. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzylisothiocyanate (cas: 2740-88-7Category: esters-buliding-blocks).
4-Fluorobenzylisothiocyanate (cas: 2740-88-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics