Synthesis, in-vitro, in-vivo anti-inflammatory activities and molecular docking studies of acyl and salicylic acid hydrazide derivatives was written by Munir, Abida;Khushal, Adil;Saeed, Kiran;Sadiq, Abdul;Ullah, Rahim;Ali, Gowhar;Ashraf, Zaman;Ullah Mughal, Ehsan;Saeed Jan, Muhammad;Rashid, Umer;Hussain, Izhar;Mumtaz, Amara. And the article was included in Bioorganic Chemistry in 2020.Product Details of 81245-24-1 This article mentions the following:
To cure the inflammation effectively and associated with side effects ,1,3,4-oxadiazole II [R= 4-Me, 4-Me-2-MeO, n=0,1] , 1,2,4-triazole III [R= 4-Me, 4-Me-2-MeO, n=0,1] , Schiff base IV [R= F, Me,MeO… n=0,1; R’ = 2-HO-4-MeO, 2-HO, -4-F, 4-HO, etc.] and 3,5-disubstituted pyrazole V derivatives were synthesized starting from salicylic acid and acyl acid hydrazides I[R = 4-Me, 3-MeO, 4-Me-2-MeO, etc., n = 0,1] as COX-1 and COX-2 inhibitors. In-vivo anti-inflammatory activities were also tested by carrageenan-induced mice paw edema against albino mice of any sex. Structures of all the synthesized compounds were confirmed by FT-IR and 1H NMR anal. Schiff base derivative of 4-aminotriazole (24) with IC50 value of 1.76 ± 0.05 (COX-2) and 117.8 ± 2.59 emerged as potent COX-2 inhibitor. Furthermore, this also performed in-vivo anti-inflammatory investigations by using carrageenan induced paw edema test. From in-vivo anti-inflammatory activities, it was found that after 1 h the maximum percentage inhibition 15.8% was observed by compound I [R= 3-OMe, n=1] which was comparable with that of the standard drug followed by the compound III[R= 4-Me, n=1] with percentage inhibition of 10.5%. After 3 h, the maximum percentage inhibition was observed by compound III [R= 4-Me, n=1] with 22.2% and compound 14 with 16.7%. After 5 h the maximum percentage inhibition was observed by compound III [R= 4-Me, n=1] with 29.4% followed by compound 16 with 23.5%. The mechanism of the inhibition by using docking simulations was also explored. Docking studies revealed that the selective COX-2 inhibitors established interactions with addnl. COX-2 enzyme pocket residues. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Product Details of 81245-24-1).
Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 81245-24-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics