Kwiatkowski, Nicholas et al. published their research in Nature Chemical Biology in 2010 | CAS: 754125-43-4

Methyl 3-(cyclopentylamino)propanoate (cas: 754125-43-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-(cyclopentylamino)propanoate

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function was written by Kwiatkowski, Nicholas;Jelluma, Nannette;Filippakopoulos, Panagis;Soundararajan, Meera;Manak, Michael S.;Kwon, Mijung;Choi, Hwan Geun;Sim, Taebo;Deveraux, Quinn L.;Rottmann, Sabine;Pellman, David;Shah, Jagesh V.;Kops, Geert J. P. L.;Knapp, Stefan;Gray, Nathanael S.. And the article was included in Nature Chemical Biology in 2010.Recommanded Product: Methyl 3-(cyclopentylamino)propanoate This article mentions the following:

Mps1, a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and for the maintenance of chromosomal stability. As Mps1 function has been implicated in numerous phases of the cell cycle, the development of a potent, selective small-mol. inhibitor of Mps1 should facilitate dissection of Mps1-related biol. We describe the cellular effects and Mps1 cocrystal structures of new, selective small-mol. inhibitors of Mps1. Consistent with RNAi studies, chem. inhibition of Mps1 leads to defects in Mad1 and Mad2 establishment at unattached kinetochores, decreased Aurora B kinase activity, premature mitotic exit and gross aneuploidy, without any evidence of centrosome duplication defects. However, in U2OS cells having extra centrosomes (an abnormality found in some cancers), Mps1 inhibition increases the frequency of multipolar mitoses. Lastly, Mps1 inhibitor treatment resulted in a decrease in cancer cell viability. In the experiment, the researchers used many compounds, for example, Methyl 3-(cyclopentylamino)propanoate (cas: 754125-43-4Recommanded Product: Methyl 3-(cyclopentylamino)propanoate).

Methyl 3-(cyclopentylamino)propanoate (cas: 754125-43-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-(cyclopentylamino)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics