Catalytic dynamic kinetic resolutions with N-heterocyclic carbenes: Asymmetric synthesis of highly substituted β-lactones was written by Cohen, Daniel T.;Eichman, Chad C.;Phillips, Eric M.;Zarefsky, Emily R.;Scheidt, Karl A.. And the article was included in Angewandte Chemie, International Edition in 2012.Safety of Ethyl 3-oxo-3-(m-tolyl)propanoate This article mentions the following:
A new NHC-catalyzed (N-heterocyclic carbenes) DKR (dynamic kinetic resolution) with β-keto esters to generate highly substituted β-lactones with excellent levels of stereoselectivity has been developed. This process takes advantage of the conditions necessary to generate the active NHC catalyst to simultaneously promote the epimerization of a β-ketoester substrate. The present study provides efficient access to highly enantioenriched β-lactones and cyclopentenes in good yield with good to excellent diastereoselectivity. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Safety of Ethyl 3-oxo-3-(m-tolyl)propanoate).
Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Ethyl 3-oxo-3-(m-tolyl)propanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics