One-Pot Synthesis of Substituted 2-Amino Isonicotinic Acids: Reminiscent of the Guareschi-Thorpe Condensation was written by Jin, Xiangle;Xing, Lidong;Deng, Daniel Da;Yan, Jun;Fu, Yan;Dong, Weitong. And the article was included in Journal of Organic Chemistry in 2022.Application In Synthesis of Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate This article mentions the following:
This work describes a concise manner to make a wide variety of mono- or disubstituted 2-amino isonicotinic acids via the corresponding 2,4-dioxo-carboxylic acid Et esters and Et 3-amino-3-iminopropionate hydrochloride. The reaction likely proceeds through an in situ decarboxylation process and is reminiscent to the Guareschi-Thorpe Condensation. In the experiment, the researchers used many compounds, for example, Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate (cas: 39163-39-8Application In Synthesis of Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate).
Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate (cas: 39163-39-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics