Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders was written by Kennedy, Alan R.;Khalaf, Abedawn I.;Scott, Fraser J.;Suckling, Colin J.. And the article was included in Acta Crystallographica, Section E: Crystallographic Communications in 2017.Application of 5930-92-7 This article mentions the following:
Nitropyrrole-based compounds, I [X = H, pentynyl], II and III are intermediates used in the synthesis of modified DNA minor-groove binders. In all four compounds, the nitro groups lie in the plane of the pyrrole ring. In compounds I [X = H, pentynyl], the ester groups also lay in the plane of the pyrrole ring. In compound II, both of the other substituents lay out of the plane of the pyrrole ring. In the case of compound III, the coplanarity extended to the second pyrrole ring and through both amide groups. In the crystals of all four compounds, layer-like structures were formed, via a combination of N-H···O and C-H···O hydrogen bonds for I [X = H], II and III, but by only C-H···O hydrogen bonds for I [X = pentynyl]. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7Application of 5930-92-7).
Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 5930-92-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics