Boy, Kenneth M. et al. published their research in ACS Medicinal Chemistry Letters in 2019 | CAS: 587-88-2

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481 was written by Boy, Kenneth M.;Guernon, Jason M.;Zuev, Dmitry S.;Xu, Li;Zhang, Yunhui;Shi, Jianliang;Marcin, Lawrence R.;Higgins, Mendi A.;Wu, Yong-Jin;Krishnananthan, Subramaniam;Li, Jianqing;Trehan, Ashok;Smith, Daniel;Toyn, Jeremy H.;Meredith, Jere E.;Burton, Catherine R.;Kimura, S. Roy;Zvyaga, Tatyana;Zhuo, Xiaoliang;Lentz, Kimberley A.;Grace, James E.;Denton, Rex;Morrison, John S.;Mathur, Arvind;Albright, Charles F.;Ahlijanian, Michael K.;Olson, Richard E.;Thompson, Lorin A.;Macor, John E.. And the article was included in ACS Medicinal Chemistry Letters in 2019.Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

A triazine hit identified from a screen of the BMS compound collection was optimized for potency, in vivo activity, and off-target profile to produce the bicyclic pyrimidine γ-secretase modulator BMS-932481. The compound showed robust reductions of Aβ1-42 and Aβ1-40 in the plasma, brain, and cerebrospinal fluid of mice and rats. Consistent with the γ-secretase modulator mechanism, increases in Aβ1-37 and Aβ1-38 were observed, with no change in the total amount of Aβ1-x produced. No Notch-based toxicity was observed, and the overall preclin. profile of BMS-932481 supported its further evaluation in human clin. trials. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics