Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity was written by Medda, Federico;Russell, Rupert J. M.;Higgins, Maureen;McCarthy, Anna R.;Campbell, Johanna;Slawin, Alexandra M. Z.;Lane, David P.;Lain, Sonia;Westwood, Nicholas J.. And the article was included in Journal of Medicinal Chemistry in 2009.SDS of cas: 33166-79-9 This article mentions the following:
The tenovins and cambinol are two classes of sirtuin inhibitor that exhibit antitumor activity in preclin. models. This report describes modifications to the core structure of cambinol, in particular by incorporation of substituents at the N1-position, which lead to increased potency and modified selectivity. These improvements have been rationalized using mol. modeling techniques. The expected functional selectivity in cells was also observed for both a SIRT1 and a SIRT2 selective analog. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9SDS of cas: 33166-79-9).
Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 33166-79-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics