Metal-free Catalytic Esterification of Aryl Alkyl Ketones with Alcohols via Free-radical Mediated C(sp3)-H Bond Oxygenation was written by Rammurthy, Banothu;Peraka, Swamy;Vasu, Amrutham;Krishna Sai, Gajula;Divya Rohini, Yennamaneni;Narender, Nama. And the article was included in Asian Journal of Organic Chemistry in 2021.Safety of Methyl 4-(2-hydroxyphenyl)butanoate This article mentions the following:
A novel metal-free catalytic one-pot approach has been developed for the esterification of aralkyl ketones RC(O)R1 (R = Ph, naphth-2-yl, 2-bromophenyl, etc.; R1 = Me, Et, benzyl) with alcs. R2OH (R2 = Me, Et, i-Pr, n-Bu) under open-air atm. conditions. The inexpensive iodide/oxone reagent system allowed the cascade C(sp3)-H bond oxygenation, selective C-C bond cleavage and esterification through the both radical and ionic pathways in a stepwise manner in one-pot. This mild, convenient and economically viable catalytic method tolerates the various functional groups to provide the corresponding alkyl benzoates RC(O)OR2 in up to 98% yields with up to 99% selectivity. The efficiency and feasibility of scale-up of the present catalytic system were demonstrated with gram scale experiments (up to 10 g scale). In the experiment, the researchers used many compounds, for example, Methyl 4-(2-hydroxyphenyl)butanoate (cas: 93108-07-7Safety of Methyl 4-(2-hydroxyphenyl)butanoate).
Methyl 4-(2-hydroxyphenyl)butanoate (cas: 93108-07-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of Methyl 4-(2-hydroxyphenyl)butanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics